I've tried my RX 460s on two prebuilt computers, a Lenovo and a HP running Sandy Bridge CPUs.
I bought two Sapphire RX 460 2GB single-fan editions and neither of the two computers want to boot, but the fans are spinning. Is this a known issue? I've tried both GPUs in other systems and it works just fine, and I know it's not a PSU issue.
Read more: Sapphire RX 460 and Sandy Bridge compatibility?